Biology 0610/43 May/June 2021: question paper and mark scheme
Cambridge IGCSE Biology (0610), Paper 4 Theory (Extended), May/June 2021. Read both free below, or download them. Done the paper? Get it marked by AI against this mark scheme.
(a) (i) The main component of milk is a liquid that is an important solvent in the body.
State the name of this solvent.
…… [1]
(ii) Table 1.1 shows some of the nutrients found in human milk, the elements that make up the nutrients, the enzymes that digest them and the products of digestion.
Complete Table 1.1.
Table 1.1
nutrient elements enzyme products of digestion
protein
fat
lactose (milk galactose and glucose
C, H, O sugar) (simple sugars)
[4]
(b) Milk also contains vitamins and mineral salts.
(i) Explain why vitamin D is important for the nutrition of children.
…… [3]
(ii) Explain why iron is important in the diet.
…… [2]
(c) Rubella and kwashiorkor are two diseases that affect children.
Rubella is a transmissible disease and kwashiorkor is a non-transmissible disease.
(i) Define the term transmissible disease.
…… [2]
(ii) Explain why women should be vaccinated against rubella before they reach reproductive age.
…… [4]
(iii) Outline the causes of kwashiorkor.
…… [2]
[Total: 18]
Mark scheme
1(a)(i) water ; 1
1(a)(ii) 4 elements for protein and fat for 1 mark
products of
enzyme and products for protein for 1 mark
nutrient elements enzyme digestion / products
enzyme and products for fat for 1 mark
absorbed into blood
enzyme for lactose for 1 mark
C, H, O, N protease /
protein (S) AND pepsin / amino acids ;
trypsin
fat C, H, O ; lipase fatty acids AND glycerol ;
lactose
galactose and glucose (simple
(milk C, H, O lactase ;
sugars)
sugar)
1(b)(i) any three from: 3
needed for (growth / development / strengthening of) bones ;
needed for (growth / development / strengthening of) teeth ;
prevents rickets ;
AVP ;
1(b)(ii) any two from: 2
required to make haemoglobin / red blood cells ;
for transport of oxygen ;
prevents (iron-deficiency) anaemia ;
AVP ;
1(c)(i) disease is caused by a pathogen ; 2
(pathogen is) passed from one host to another ;
1(c)(ii) any four from: 4
rubella is caused by a virus ;
(virus) can cross the placenta ;
(virus) can affect embryo / fetus ;
can cause serious, disease / damage / death, to baby / offspring ;
vaccination stimulates, long-lasting / active, immunity (in the mother) ;
(immunity gained) before they become pregnant ;
AVP ;
1(c)(iii) not enough protein (in the diet) ; 2
adequate energy (in the diet) ;
inadequate diet after breast feeding finishes / AW ;
Insulin is a protein made by cells in the pancreas.
Fig. 2.1 shows how insulin is made in a pancreatic cell.
DNA amino acids
nucleus
amino acids assembled to form insulin
A
B not to scale
Fig. 2.1
(a) (i) State the name of molecule A in Fig. 2.1.
…… [1]
(ii) State the name of structure B in Fig. 2.1.
…… [1]
(iii) Explain the role of molecule A in protein synthesis, as shown in Fig. 2.1.
…… [3]
(b) Insulin is secreted from cells in the pancreas when the concentration of glucose in the blood increases.
Outline the role of insulin.
…… [4]
(c) State the names of two substances, other than insulin, that are secreted by the pancreas.
1 ……
2 ……
[2]
[Total: 11]
Mark scheme
2(a)(i) mRNA / messenger RNA ; 1
2(a)(ii) ribosome ; 1
2(a)(iii) any three from: 3
molecule A / mRNA, is a copy of the gene (for insulin) ;
transfers instructions from, DNA / nucleus, to, cytoplasm / ribosome / B ;
passes through B ;
sequence of bases determines the order of amino acids ;
2(b) insulin is a hormone ; 4
stimulates liver (cells and muscle cells) ;
to, absorb / take up, glucose / sugar, from the blood ;
across cell membranes ;
stimulates production of glycogen (in cells) / AW ;
reduces concentration of, glucose / sugar, in the blood ;
homeostasis ;
AVP ;
2(c) any two from: 2
glucagon / hormone ;
amylase ;
trypsin / protease ;
lipase ;
AVP ;;
Scientists measured the rate of photosynthesis in the leaves of a sunflower plant, Helianthus annuus.
The scientists used the apparatus shown in Fig. 3.1 to measure the rate of photosynthesis.
direction of air flow
air flow regulator chamber 1 chamber 2 chamber 3
temperature 20 °C
CO2 360 ppm
CO2 400 ppm timer
00:00
Fig. 3.1
(a) The apparatus in Fig. 3.1 maintains a constant temperature and a constant humidity.
(i) Explain why temperature has an effect on the rate of photosynthesis.
…… [4]
(ii) Explain why the rate of photosynthesis will decrease if the humidity in the apparatus becomes very low.
…… [3]
(iii) The apparatus was left for 15 minutes.
Explain how the scientists would use the readings for the concentration of carbon dioxide in chambers 1 and 3 to calculate the rate of photosynthesis.
…… [2]
(b) The scientists carried out another investigation using the same apparatus at different temperatures.
They measured the rate of uptake of carbon dioxide in the light and then they measured the rate of release of carbon dioxide in the dark.
The results are shown in Fig. 3.2.
160
140
CO2 uptake
120 in the light
rate of carbon 100 dioxide uptake and release 80
/ μg per hour per cm2 of leaf
60
CO2 release
40 in the dark
20
0
15 20 25 30 35 40 temperature / °C
Fig. 3.2
(i) Use the information in Fig. 3.2 to complete Table 3.1.
Table 3.1
temperature rate of uptake of carbon dioxide in rate of release of carbon dioxide in
/ °C the light / μg per hour per cm2 of leaf the dark / μg per hour per cm2 of leaf
20
35 90 45
[2]
(ii) The scientists determined that photosynthesis in the leaves at 35 °C used carbon dioxide at a rate of 135 μg per hour per cm2 of leaf. Fig. 3.2 shows that the rate of carbon dioxide uptake at 35 °C was 90 μg per hour per cm2 of leaf.
Explain why the rate at which carbon dioxide is used in photosynthesis is greater than the rate of carbon dioxide uptake.
…… [2]
(iii) Explain why the results in Table 3.1 are expressed as ‘per cm2 of leaf’ rather than ‘per leaf’.
…… [1]
(c) Some crops are grown in controlled environments. Glasshouses are an example of a controlled environment. Fig. 3.3 shows a glasshouse where lettuces are growing.
Fig. 3.3
Discuss the advantages of growing crops in glasshouses.
…… [6]
[Total: 20]
Mark scheme
3(a)(i) any four from: 4
(photosynthesis involves) enzymes / AW ;
increase in temperature increases rate (of photosynthesis) / ora ;
increases kinetic energy of molecules ;
increases effective collisions between enzyme and substrate
molecules / ora ;
reaction will have an optimum temperature ;
high temperature denatures enzymes ;
increases rate of diffusion ;
increased uptake of carbon dioxide molecules into leaf ;
3(a)(ii) any three from: 3
air becomes very dry ;
ref. to increasing the diffusion gradient for water vapour ;
from the air spaces in the leaf into the air surrounding the leaf ;
increases rate of transpiration ;
stomata close ;
carbon dioxide cannot enter ;
3(a)(iii) record the difference (in concentration of carbon dioxide) (between air in 2
and air out / between chamber 1 and 3 / before and after) ;
divide by, the time / 15 min ;
3(b)(i) CO2 uptake: 136 ; 2
CO2 release: 20 ;
3(b)(ii) any two from: 2
carbon dioxide produced in respiration ;
plants respire all the time ;
carbon dioxide released in the dark is produced by respiration ;
carbon dioxide released by cells is used in photosynthesis ;
3(b)(iii) any one from: 1
leaves have different surface areas ;
so, valid / AW, comparisons can be made ;
3(c) any six from: 6
1 glasshouses can maintain, optimum / AW, conditions for
photosynthesis ;
2 ref. to limiting factors for, photosynthesis / growth ;
3 to increase yield / continuous production / production independent of
seasons ;
ref. to control of light
4 (can, achieve / maintain) optimum, light / light intensity / wavelength ;
5 light duration / use artificial lights (and timers / light sensors) ;
ref. to control of temperature
6 (can, achieve / maintain) optimum temperature ;
7 heater / cooling / idea of ventilation ;
ref. to control of carbon dioxide
8 (can use) carbon dioxide enrichment / high carbon dioxide
concentration ;
9 burn (named) fuels / pump in carbon dioxide ;
ref. to control of water and nutrients
10 water supply / humidity ;
11 nutrients / minerals ;
12 irrigation / fertigation / misting / hydroponics / described ;
ref. to control of pests and weeds
13 pest control ;
14 any type described ; e.g. biological control / chemical control
15 herbicides not required ;
additional points
16 computer control / automation (described) ;
17 efficient use of land / use brownfield sites / local food near markets ;
18 reduction in pollution by, fertilisers / pesticides ;
19 control of pollinators for selective breeding ;
There are three species of rhinoceros in Asia. Fig. 4.1 shows an Indian rhinoceros, Rhinoceros unicornis, in a national park being observed by tourists who are riding on an elephant.
Fig. 4.1
The International Union for Conservation of Nature (IUCN) collects data on animal species and places them into categories based on estimated numbers.
Table 4.1 summarises the conservation status of the three species of rhinoceros, as available in
2020.
Table 4.1
approximate approximate species location number in number in IUCN category the wild captivity
Indian rhinoceros national parks
Rhinoceros in south Nepal 3588 160 vulnerable unicornis and north India
Javan rhinoceros one national
Rhinoceros park in Java, 72 0 critically endangered sondaicus Indonesia
Sumatran national parks rhinoceros in Sumatra
<80 7 critically endangered
Dicerorhinus and Borneo in sumatrensis Indonesia
(a) Outline the reasons why large mammals, such as some species of rhinoceros, are endangered.
…… [5]
(b) In 2013, Cincinnati Zoo in the USA announced that they were hoping to breed together rhinoceros that were brother and sister as part of their captive breeding programme.
(i) Discuss the problems that using such closely related animals might have for the conservation of rhinoceros.
…… [2]
(ii) Captive breeding programmes often use artificial insemination.
Outline the process of artificial insemination.
…… [3]
[Total: 10]
Mark scheme
4(a) any five from: 5
1 habitat loss / deforestation ;
2 large mammals need large amounts of space ;
3 (named example of) climate change ; e.g. desertification
use of land for
4 land developed for agriculture ;
5 land developed for, housing / transport / factories / AW ;
6 land used for extraction of (named) material(s) ;
7 competing with humans for space ;
8 idea that populations are isolated ;
9 hunt / trophies / high value / poaching ;
10 laws are not enforced to protect from hunting ;
11 lack of education ;
12 poisoning / pollution ;
13 need a large quantity of food / lack of food sources / starvation ;
14 slow reproduction rate / hard to breed in captivity ;
15 AVP ;
4(b)(i) any two from: 2
inbreeding / AW ;
reduce (genetic) variation ;
(reduced variation) less able to respond to, environmental
changes / disease ;
increase in homozygosity / described in terms of alleles ;
increase chance of genetic disease(s) / birth defects ;
any example ; e.g. lameness
increase chance of infertility ;
4(b)(ii) any three from: 3
1 collect semen / sperm (implied by context) ;
2 freeze semen / sperm, / use sperm bank / use sperm collected, far
away/ long ago ;
3 selecting / washing / screening, of sperm / AW ;
4 use hormones for (super)ovulation ;
5 determine when female is about to ovulate ;
6 insert, semen / sperm, into female (vagina / uterus) ;
(a) Table 5.1 shows four functions of the human gas exchange system.
Complete Table 5.1 by identifying the part of the human gas exchange system that carries out each function.
Table 5.1
part of the human gas exchange function system
contracts to decrease air pressure in the lungs
allows air to flow between the larynx and the lungs
contracts to lower the ribs in forced expiration
site of gas exchange
[4]
(b) Scientists investigated the effect of increasing carbon dioxide concentration in the air on the rate and depth of breathing. The people who took part in the investigation were healthy volunteers.
The people breathed atmospheric air containing 0.04% carbon dioxide for five minutes.
They then breathed air containing 2% carbon dioxide for five minutes and then returned to breathing atmospheric air for a further five minutes.
The results are shown in Fig. 5.1.
0.04% CO2 2% CO2 0.04% CO2
70
60
50
40
percentage 30 change in rate and depth of breathing 20
10
0
0 2 4 6 8 10 12 14 16
–10
–20 time / minutes key: rate of breathing depth of breathing
Fig. 5.1
Describe the effects of changing the carbon dioxide concentration of the air on the rate and depth of breathing, as shown in Fig. 5.1.
…… [4]
(c) Complete the sentences by writing the appropriate word or phrase in the spaces provided.
During physical activity the carbon dioxide concentration in the blood increases. The
reason for this is an increase in the rate of …… that occurs in the
…… in muscle cells.
The increase in the concentration of carbon dioxide in the blood is detected by the
…… , which increases the rate and depth of breathing so that carbon
dioxide can be …… from the body. This is important because carbon
dioxide is a …… substance and can cause harm if it accumulates.
[5]
[Total: 13]
Mark scheme
5(a) diaphragm / external intercostal muscles ; 4
trachea / bronchus ;
internal intercostal muscles ;
alveolus / alveoli ;
5(b) any four from: 4
1 (rate and depth of breathing) increase when carbon dioxide
concentration increases ;
2 depth of breathing levels off at 9–10 minutes while rate of breathing
still going up ;
3 larger increase in rate of breathing than the depth of breathing ;
4 both rate and depth of breathing decrease when the carbon dioxide
concentration decreases ;
5 rate and depth of breathing decrease below zero (percentage
change) ;
6 rate of breathing does not / depth of breathing starts to, return to zero
(percentage change);
7 use of comparative figures for rate of breathing ;
8 use of comparative figures for depth of breathing ;
5(c) respiration ; 5
mitochondria ;
brain ;
excreted / AW ;
toxic / poisonous / waste / acid(ic) ;
There are four blood groups in the ABO system in humans: A, B, AB and O.
The gene that determines blood group has three alleles: IA, IB and Io.
(a) Parents with the genotypes IAIo and IBIo are planning to have more children.
Complete the genetic diagram to determine the probability that the next child will have blood group O.
parental blood groups A B
parental genotypes IAIo IBIo
Punnett square
phenotypes of the children ……
probability that the child will have blood group O ……
[4]
(b) Explain why the ABO blood group system is an example of co-dominance.
…… [2]
(c) Fig. 6.1 shows the percentages of the global population with the four different blood groups in the ABO system.
45
40
35
30
percentage 25 of the global population
20
15
10
5
0
A B AB O blood group
Fig. 6.1
With reference to Fig. 6.1, explain why the ABO blood group system is an example of discontinuous variation.
…… [2]
[Total: 8]
Mark scheme
6(a) 4 one mark for four correct gametes in Punnett
IA IO square
one mark for four correct offspring genotypes
IAIB
IB IB IO in Punnett square
;;
IO IAIO IOIO
phenotypes of the children: AB, B, A, O ;
probability…blood group O: 0.25 / 25% / 1 in 4 ;
6(b) both / two, alleles are expressed in, heterozygote / phenotype / AW ; 2
ref. to, blood group AB / IAIB ;
6c) any two from: 2
phenotype is determined only by a gene ;
no effect of environment on phenotype ;
only, four / limited number of, phenotypes / (blood) groups / categories ;
no intermediates between categories ;
Checked your answers against these? Let AI mark the whole paper, on your own working.
Examiners follow the generic marking principles at the front of the scheme, then each question's points: method (M), accuracy (A) and independent (B) marks, error carried forward where the scheme allows it, and positive marking, so you're credited for what you got right.
Check your answers against it
Done this paper? Upload your script and CIE Buddy's AI marker marks it question by question against this exact scheme, puts the ticks on your own working and says what each lost mark needed.
Where can I find the 0610/43 May/June 2021 mark scheme?+
On this page, free: the mark scheme for IGCSE Biology 0610/43, May/June 2021 (0610_s21_ms_43), and the question paper (0610_s21_qp_43), to read or download, with each question's marking points written out underneath.
How many marks is 0610/43 out of?+
Biology 0610/43 for May/June 2021 is out of 80 marks, with 1 hour 15 minutes to answer it, across 6 questions.
Can I get my 0610/43 answers marked?+
Yes. Upload your answers to 0610/43/M/J/21 as a PDF or photos, and CIE Buddy marks every question against this paper's official mark scheme, using Cambridge's marking rules. You get your score, each lost mark explained on your own script, and the topics to revise. It's a guide, not an official Cambridge grade.