Biology 0610/43 October/November 2022: question paper and mark scheme
Cambridge IGCSE Biology (0610), Paper 4 Theory (Extended), October/November 2022. Read both free below, or download them. Done the paper? Get it marked by AI against this mark scheme.
(a) Fig. 1.1 is a diagram showing parts of two organ systems that are active when a person sneezes.
J
K
P
O
L
M
N
view of part of the gas exchange system view of part of the nervous system
not to scale
Fig. 1.1
(i) Sneezing is an automatic action that occurs in response to a stimulus in the nose.
State the name of this type of automatic action.
…… [1]
(ii) Table 1.1 shows the names and functions of some of the parts of the human body that are involved when a person sneezes, and the letters in Fig. 1.1 that identify these parts.
Complete Table 1.1.
Table 1.1
function name of structure letter in Fig. 1.1
cell that transmits an impulse from the receptor to the central nervous system
diaphragm
M
K
contains cilia to move mucus out of the airway
[5]
(b) Fig. 1.2 is a diagram of a cell from the human nervous system.
Fig. 1.2
(i) On Fig. 1.2, label two visible cell structures. [2]
(ii) Draw an X on the cell in Fig. 1.2 to show where a receptor molecule for a neurotransmitter would be found. [1]
(iii) Explain how the cell in Fig. 1.2 is adapted for transmitting impulses.
…… [2]
(c) Describe how nervous communication differs from hormonal communication.
…… [3]
[Total: 14]
Mark scheme
1(a)(i) reflex ; 1
1(a)(ii) 5 one mark per row
letter
in
function name of structure
Fig.
1.1
cell that transmits impulse from
the receptor to the central nervous sensory neurone J
system
changes the, volume / (air)
diaphragm N
pressure, in the thorax / AW
coordinates / controls /
communicates / regulates / AW,
body functions / responses /
reflexes
spinal cord / CNS M
or
connects, neurones / brain / CNS,
and (named part of) body / PNS /
neurones
transmits / sends, impulses (in,
CNS / M) relay / AW,
K
or neurone
connects neurones
contains cilia to move mucus out
trachea P
of the airway
;;;;;
1(b)(i) any two labels to correct structure on Fig.1.2: 2
nucleus ;
cell membrane ;
cytoplasm ;
AVP ; e.g. cell body / axon / dendrite
1(b)(ii) X drawn at any tip of left-hand side of the motor neurone ; 1
1(b)(iii) any two from: 2
1 axons / long, to transmit (impulse), over (long) distance /
fast / direct connection ;
2 (many) branches to connect to, other / relay, neurones /
cells / effector / muscle ;
3 mitochondria to (release energy), for, transmission of
impulse / protein synthesis / active transport / making or
releasing (neuro)transmitters ;
4 vesicles to, carry / hold / release, chemicals /
(neuro)transmitters (into synapse) ;
5 receptor (molecules), to ensure unidirectional transmission /
to allow signal to be received by next neurone ;
6 AVP ; MP6 e.g. dendrites have large surface area for many
receptors
1(c) any three from: 3
nerve communication is: hormonal communication is:
1 faster / ora ;
2 shorter-lasting / ora ;
3 specific / one, target / location ; MP3 widespread / can have multiple target organs
4 electrical (and chemical) ; A uses impulses MP4 chemical (only)
5 conducted through cells / uses neurones / uses nerves / uses MP5 (travels through) blood / plasma / circulatory system
CNS ; or released from, glands / endocrine system
6 AVP ; MP6 e.g. can be voluntary
(a) Digestive enzymes are secreted into the alimentary canal.
(i) As well as enzymes, other substances that are important for digestion are also secreted into the alimentary canal.
State the names of two of these other substances.
1 ……
2 ……
[2]
(ii) Table 2.1 summarises some facts about the enzymes that are secreted into the alimentary canal.
Complete Table 2.1.
Table 2.1
products of organ where the organ when the name of the enzyme digestion involving this enzyme is secreted enzyme acts enzyme
salivary glands
pepsin
pancreas fatty acids and glycerol
epithelial lining of the small intestine small intestine
[4]
(b) The activity of the enzyme pepsin was measured at different temperatures.
The results are shown in Fig. 2.1.
3000
2500
2000
enzyme activity
1500
/ U per mg protein
1000
500
0
10 20 30 40 50 60 70 temperature / °C
Fig. 2.1
Describe and explain the effect of temperature on the activity of pepsin.
Use the information in Fig. 2.1 to support your answer.
…… [6]
(c) Lactase is another digestive enzyme, which is produced by human babies.
(i) Explain why lactase is important for the nutrition of young babies.
…… [2]
(ii) Most people stop producing lactase when they become adults. If they drink milk, this may give them diarrhoea.
Describe the symptoms of diarrhoea.
…… [1]
(iii) Cholera can also cause diarrhoea.
Explain how the cholera bacterium causes diarrhoea.
…… [3]
[Total: 18]
Mark scheme
2(a)(i) any two from: 2
bile ;
(hydrochloric) acid ;
mucus / water / saliva ;
AVP ;
2(a)(ii) 4 one mark for each correct row
products of
organ where organ where
name of digestion
enzyme is the enzyme
enzyme involving this
secreted acts
enzyme
simple(r)
salivary mouth / buccal sugars
amylase
glands cavity / maltose
/ glucose
stomach
pepsin / gastric stomach amino acids
glands
small intestine
fatty acids and
lipase pancreas / duodenum
glycerol
/ ileum
epithelial lining
maltase small intestine of the small glucose
intestine
;;;;
2(b) any six from: 6 each unit must be stated at least once
1 39 ± 2 oC is optimum temperature / AW ; ecf on wrong or no units
2 highest activity is 2500 U per mg (protein) ;
3 steep(er) decrease in activity after optimum / ora ;
4 no activity after 62 oC ± 2 ;
5 (increased) temperature causes increased kinetic energy /
ora ;
6 increased frequency of (effective) collisions / ora ;
7 forming enzyme-substrate complexes / ora ;
8 denaturation occurs (at any temperatures above optimum
temperature) ;
9 active site changes shape ;
10 no longer, fit into substrate / complementary (to substrate) ;
11 idea that both enzyme and substrate are proteins and may
change ;
2(c)(i) any two from: 2
lactose is found in milk ;
lactase breaks down lactose ;
(young) babies are dependent on, lactose / milk (for their
nutrition) / AW ;
2(c)(ii) (loss of) watery faeces / AW ; 1
2(c)(iii) any three from: 3
(cholera bacterium) release toxins ;
causes chloride ions (to be secreted from the body) ;
(chloride ions) in small intestine / duodenum / ileum ;
ref to osmotic movement / lowers water potential (in gut) ;
water moves into gut or more water remains, in intestines / gut ;
Fig. 3.1 shows the estimated growth of the global human population between the 1860s and
2010s.
It also shows the estimated number of people that were affected by famines between these dates.
22
20
18
16 8
14 7 estimated number of 12 6 people affected by famines 10 5
/ million estimated global human
8 4 population
/ billion
6 3
4 2
2 1
0 0
18 0s
18 0s
18 0s
19 0s
19 0s
19 0s
19 0s
19 0s
19 0s
19 0s
19 0s
19 0s
19 0s
20 0s
20 0s s
10
6
7
8
9
0
1
2
3
4
5
6
7
8
9
0
18
time / decade
1 billion = 1 000 000 000
Key: estimated number of people affected by famines estimated global human population
Fig. 3.1
(a) (i) State the final size of the estimated global human population shown in the 2010s in
Fig. 3.1.
…… [1]
(ii) Using the information in Fig. 3.1, calculate the percentage of the estimated global human population that was affected by famine during the 1860s.
Give your answer to one significant figure.
…… %
[2]
(b) An increase in the size of the human population can cause famine.
(i) Describe other factors that could have caused famines since the 1970s.
…… [3]
(ii) Chemical fertilisers have helped farmers to increase food production.
Discuss the negative impact on the natural environment of using chemicals, other than fertilisers, in modern farming methods.
…… [4]
(iii) Crops are often grown as monocultures.
State what is meant by a monoculture.
…… [1]
(iv) Scientists are developing crop plants that can produce antigens so that people gain immunity to different diseases such as hepatitis B.
State the process which can be used to develop crop plants that can produce proteins from other species.
…… [1]
[Total: 12]
Mark scheme
3(a)(i) 7.6 billion / 7 600 000 000 / 7.6 × 109 ; 1
3(a)(ii) 0.3(%) ;; 2 MP1 correct calculation
MP2 correct rounding to 0.3(%)
ecf if wrong values used in the calculation
3(b)(i) any three from: 3
(named crop) disease ;
war ;
drought / AW ;
flooding / AW ;
unequal distribution of food / AW ;
(widespread) poverty ;
AVP ; MP7 e.g. plagues of crop pests
3(b)(ii) any four from: 4
1 one named chemical (other than fertilisers) used in farming ; MP1 examples: herbicides / 2,4 D / weedkillers /
pesticides / insecticides / antibiotics / plant growth
pesticides / insecticides / herbicides: regulators / (animal) hormones
2 kill / harm, non-target species (in natural environment) ;
3 example of specific impact from harm of non-target MP3 e.g. loss of pollination (by bees)
species ;
4 loss of biodiversity / disrupt food chains ;
5 bioaccumulation / bioconcentration / biomagnification ; MP5 A descriptions
6 ref to resistant organisms or super, bugs / weeds ;
7 pollute / destroy / AW, non-target / named, area / habitat ;
8 (antibiotics cause) antibiotic-resistance ;
9 AVP ; MP9 changes / increases, the pH of soil
3(b)(iii) a single crop in production / AW ; 1
3(b)(iv) genetic, engineering / modification ; 1
(a) Fig. 4.1 shows a dandelion plant, Taraxacum officinale, in a field. The flower stalk is called a scape.
scape
Fig. 4.1
(i) The scape of a dandelion responds to sunlight by growing upwards.
State the name of this growth response.
…… [1]
(ii) The scapes of dandelions keep the plant upright without the need for structures such as bones.
Explain how cells in plant scapes and stems keep plants upright.
…… [2]
(b) Fig. 4.2 is part of a cross-section through the scape of a dandelion.
Fig. 4.2
Draw a line and add a label on Fig. 4.2 to identify one area of xylem tissue. [1]
(c) Describe the function of phloem tissue.
…… [3]
(d) A dandelion scape was cut into long strips for an osmosis investigation.
Immediately after the scape was cut, the pieces of scape bent outwards, as shown in Fig. 4.3.
scape cut into long strips
inner part of scape that can absorb or lose water
outer part of scape that cannot absorb or lose water
Fig. 4.3
Key:
A B inner sur outer sur
C D
not to sca that can absorb or lose water
17 outer part of scape that cannot absorb
Strips or lose water of dandelion scape were placed in four dishes, A, B, C and D, for 30 minutes.
Each dish contained a different concentration of salt solution.
Fig. 4.4 shows the appearance of the four strips of scape after 30 minutes.
Key:
A B inner surface of scape outer surface of scape
C D
not to scale
Fig. 4.4
Using the information in Fig. 4.3 and Fig. 4.4, deduce and explain which strip of scape was in the most concentrated salt solution.
strip of scape ……
explanation ……
[3]
[Total: 10]
Mark scheme
4(a)(i) (positive) phototropism ; 1
4(a)(ii) any two from: 2
(plants have) cell walls ;
pressure of water pressing against cell wall / ref. to turgor ;
ref. to xylem (offering support) ;
AVP ; MP4 e.g. ref. to lignin
4(b) label to xylem shown on Fig. 4.2 ; 1
4(c) any three from: 3
1 translocation ;
2 transport of, sucrose / amino acids / sugars ;
3 (transports nutrients) from (named) source to (named) sink ;
4 AVP ; MP4 e.g. transport can occur in both directions
some organs can be both a source and / or a sink at
different times
4(d) strip of stalk: 3
1 B;
explanation, max two from:
2 shows greater degree of, bending / shrivelling / AW ;
3 because more water moves out (of the cells in the inner
surface of the scape) ;
4 (water moves) from high water potential to, lowest water MP4 A (cells become) plasmolysed / flaccid / less turgid
potential / lower water potential ;
(a) Researchers investigated water pollution in the centre of a lake for 11 days.
Fig. 5.1 shows researchers collecting samples of aquatic organisms from the lake with a net which was placed at a specified water depth.
Fig. 5.1
Each day, the researchers collected 5 dm3 of water from the lake. Fish and other large organisms were released back into the lake. The researchers extracted the chlorophyll from all the microorganisms that were collected in the sample of lake water.
They determined the concentration of chlorophyll by measuring the mass of chlorophyll extracted from each dm3 of lake water.
Fig. 5.2 shows a researcher lowering a Secchi disc on a long string into a lake from a boat.
A Secchi disc is a plastic disc which is divided into black and white sections. It is used to measure the transparency of water in lakes, rivers and oceans.
The researcher recorded the maximum water depth at which the Secchi disc was still visible.
Secchi disc
Fig. 5.2
The results of the investigation are shown in Fig. 5.3.
6 1.0
5 1.5
4 2.0 maximum water concentration depth at which of chlorophyll 3 2.5 the Secchi disc
/ mg per dm3 is visible / m
2 3.0
1 3.5
0 4.0
1 2 3 4 5 6 7 8 9 10 11 day
Key: concentration of chlorophyll maximum water depth at which the Secchi disc is visible
Fig. 5.3
(i) State the type of microorganism that contains chlorophyll.
…… [1]
(ii) The researchers collected 5 dm3 of water from the lake each day. Using this information and the information in Fig. 5.3, calculate the total mass of chlorophyll in the sample on day 1.
Include the appropriate units with your answer.
[2]
(iii) Suggest why the researchers determined the concentration of chlorophyll rather than counting the number of microorganisms in the sample.
…… [1]
(iv) Using the information in Fig. 5.3, identify the day when the water was the most transparent.
…… [1]
(v) Explain why the transparency of the water is important for organisms that contain chlorophyll.
…… [2]
(b) (i) Heavy rainfall in nearby fields caused ions from fertilisers to wash into the lake on day 1 of the investigation.
State which ions can cause an increase in the number of organisms that contain chlorophyll in the lake.
…… [1]
(ii) Many of the organisms that contain chlorophyll died on day 2 of the investigation.
Explain the consequences of the death of these organisms to the lake ecosystem.
…… [3]
(c) The researchers monitored the water in the lake for pollution.
Outline how sewage should be treated so that the water it contains is safe to put into the lake.
…… [5]
[Total: 16]
Mark scheme
5(a)(i) (some) protoctists / algae ; 1 A (cyano)bacteria / (phyto)plankton
5(a)(ii) 15 ; 2 (3.0)×5
mg ;
A 0.015 g for 2 marks
5(a)(iii) any one from: 1
(organisms) too small / difficult, to count ;
AVP ; e.g. easier to measure (in outdoor environment) / there
are microorganisms that do not have chlorophyll / (more)
accurate / time-efficient
5(a)(iv) (day) 8 ; 1
5(a)(v) any two from: 2
to absorb / receive, (enough) light (energy) ;
(light) is necessary for photosynthesis ;
(for the organisms) to make sugars / starch / to convert light MP3 A because they are producers / for growth (of
(energy) into chemical energy ; organisms)
5(b)(i) any one from: 1
nitrate / NO3- ;
AVP ; e.g. magnesium
5(b)(ii) any three from: 3
1 eutrophication ;
2 increase in, decomposition / number of (named)
decomposers ;
3 decomposers respire aerobically ;
4 decomposition causes a reduction in (dissolved) oxygen ; MP4 I because there is less photosynthesis
5 (reduced oxygen) causes death of fish / (named aquatic)
animals / AW ;
6 (death of producers means) less food for consumers / loss
of biodiversity / knock on effect further along food chain ;
5(c) any five from: 5
1 screening / removal of, large pieces of waste ;
2 flocculation / coagulation / clump suspended particles / AW ;
3 settling of, (insoluble) particles ;
4 digestion / decomposition by, (aerobic) bacteria / fungi / MP3 A ref to sedimentation / (use of) settlement tank
decomposers / microorganisms ;
5 (with) aeration (tank) / trickle filter / activated sludge ;
6 sludge treated with anaerobic decomposers / anaerobic MP5 A with oxygen / description of a trickle filter
digestion ;
7 (water) treated with, chlorine / ozone / UV (light) ; MP7 A reverse osmosis / disinfect
8 distillation / collection of water from evaporator ; MP8 A use of carbon / charcoal, filters
Plants can be classified according to the position and shape of the structures in their flowers.
(a) Fig. 6.1 shows sections of flowers from six different plant species.
A B
C D
E F
Fig. 6.1
(i) Use the key to identify each species. Write the letter of each species (A to F) in the correct box in the key.
key
1(a) two petals visible go to 2
(b) three petals visible go to 4
2(a) one stigma per flower go to 3
(b) more than one stigma per flower Pyrus communis
3(a) stigma higher than anther Prunus domestica
(b) stigma at same level or lower than anther Prunus salicina
4(a) two ovules visible go to 5
(b) more than two ovules visible Punica granatum
5(a) anther smaller than carpel Prunus amygdalus
(b) anther larger than carpel Olea europaea
[4]
(ii) The large petals of the flowers shown in Fig. 6.1 indicate that they are pollinated by insects.
List four other structural adaptations of insect-pollinated flowers.
1 ……
2 ……
3 ……
4 ……
[4]
(b) Flowering plants are distinguished from ferns because they all produce flowers.
State one other morphological feature that can be used to distinguish flowering plants from ferns.
…… [1]
(c) The fruit of a pear tree, Pyrus communis, is often used to make juice.
State what protein biotechnologists will use to increase the volume of juice produced from pear fruit.
…… [1]
[Total: 10]
Mark scheme
6(a)(i) 4 6 correct = 4 marks
go to 2 4 or 5 correct = 3 marks
2 or 3 correct = 2 marks
go to 4 1 correct = 1 mark
go to 3
Pyrus communis D
Prunus domestica A
Prunus salicina B
go to 5
Punica granatum E
Prunus amygdalus C
Olea europaea F
;;;;
6(a)(ii) any four from: 4
nectary / nectar ;
sticky / spiky / AW, pollen ;
sticky stigma ;
stigmas / style / carpel, within flower / AW ;
anthers / stamens, within flower / AW ;
colourful petals ;
AVP ; MP7 e.g. nectar guides (on petals) / robust stigma
/ robust style / landing site
6(b) features of flowering plants 1 accept parts of a fern for ora
any one from: A ferns have, spores / fronds / underground stems
pollen ;
ovule(s) ;
(named part of) seed ;
fruit ;
leaves ;
aerial stems ;
AVP ;
6(c) pectinase ; 1
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Biology 0610/43 for October/November 2022 is out of 80 marks, with 1 hour 15 minutes to answer it, across 6 questions.
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