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Biology 0610/22 October/November 2025: question paper and mark scheme

Cambridge IGCSE Biology (0610), Paper 2 Multiple Choice (Extended), October/November 2025. Read both free below, or download them. Done the paper? Get it marked by AI against this mark scheme.

0610_w25_qp_220610_w25_ms_220610/22/O/N/25

Paper
Paper 2 Multiple Choice (Extended)
Total marks
40
Time
45 minutes
Code on the paper
0610/22/O/N/25
0610_w25_ms_22.pdf

0610/22 answers, question by question

Each question and its answer from the key, as text. Diagrams and graphs are in the question paper above.

Question 11 mark

Question

The photographs show two different rats. Rattus norvegicus Rattus rattus Which statement about the rats is correct? A The rats belong to the same genus. B The rats belong to the same species. C The rats can breed together to produce fertile offspring. D The rats do not share any of the same features.

Answer

A

Question 21 mark

Question

The diagrams show cells of organisms from three different kingdoms. not to scale 1 2 3 Which row shows the kingdoms for the organism cells labelled 1, 2 and 3? cell 1 cell 2 cell 3 A fungus protoctist prokaryote B fungus prokaryote protoctist C prokaryote fungus protoctist D prokaryote protoctist fungus

Answer

B

Question 31 mark

Question

The diagram shows a plant cell. A biologist wants to find out the number of chromosomes it contains. Which labelled part should be examined more closely? B C A D

Answer

A

Question 41 mark

Question

Which term describes each structure? structure brain liver neurone A organ organ cell B organ tissue cell C tissue organ tissue D tissue cell organ

Answer

A

Question 51 mark

Question

The diagram shows the order of bases along part of one strand of DNA. What is the order of bases on the complementary part of the other strand?

Answer

D

Question 61 mark

Question

Which substance is an enzyme? A fibrinogen B mRNA C pepsin D saliva

Answer

C

Question 71 mark

Question

Which function is performed in the duodenum? A assimilation B digestion C egestion D ingestion

Answer

B

Question 81 mark

Question

The graph shows the changes in pH in the oesophagus, stomach and duodenum. 12 11 10 9 8 X 7 pH 6 5 4 3 2 1 0 oesophagus stomach duodenum region of the alimentary canal Which substance causes the change in pH at the point labelled X? A bile B gastric juice C glucagon D trypsin

Answer

A

Question 91 mark

Question

Which row names a small molecule and where that molecule is absorbed in the digestive system? name of the small colon small molecule intestine A amino acid key B glucose = molecule is absorbed C maltose = molecule is not absorbed D water

Answer

D

Question 101 mark

Question

A student cut one stalk of celery from a celery plant. They put the celery stalk into a beaker of blue dye. The celery stalk was removed from the blue dye after two hours and was cut into sections. celery stalk blue dye two hours blue circles visible in the cut section What is shown by the blue circles in the cut sections of celery stalk? A position of the cortex cells B position of the palisade cells C position of the phloem cells D position of the xylem vessels

Answer

D

Question 111 mark

Question

Which process moves water from the surfaces of the mesophyll cells into the air spaces during transpiration? A active transport B circulation C evaporation D osmosis

Answer

C

Question 121 mark

Question

The mass of water lost from a plant was investigated. The leaves of the plant were covered with a type of grease that acts as a waterproof barrier. The environmental conditions remained the same throughout the experiment. The table shows the results of the investigation. mass lost in treatment seven days / g no grease applied 12.0 grease applied only to the upper surface of every leaf 8.7 grease applied to both surfaces of every leaf 0.0 What is the mean daily rate of water loss through the upper surface of the leaves? A 0.47 g / day B 1.24 g / day C 1.71 g / day D 3.30 g / day

Answer

A

Question 131 mark

Question

What is translocation? A the movement of amino acids and water from sink to source B the movement of starch and water from source to sink C the movement of sucrose and amino acids from source to sink D the movement of sucrose and mineral ions from sink to source

Answer

C

Question 141 mark

Question

Which row names the blood vessel containing the highest blood urea concentration and the blood vessel containing the lowest blood urea concentration? highest blood urea lowest blood urea concentration concentration A hepatic artery hepatic vein B hepatic vein renal vein C hepatic portal vein renal artery D renal vein hepatic portal vein

Answer

B

Question 151 mark

Question

The diagram shows the human digestive system. Where do cholera bacteria cause the secretion of chloride ions? mouth A B D C anus

Answer

D

Question 161 mark

Question

Which row describes what happens when breathing in? external intercostal diaphragm muscles A contracts contract B contracts relax C relaxes contract D relaxes relax

Answer

A

Question 171 mark

Question

A person exercised vigorously for one minute and then rested for one hour. Which statements about lactic acid are correct? 1 During exercise, lactic acid is produced in the muscles and diffuses into the blood. 2 The blood transports lactic acid to the liver. 3 Lactic acid is broken down by anaerobic respiration. A 1, 2 and 3 B 1 and 2 only C 2 and 3 only D 2 only

Answer

B

Question 181 mark

Question

The diagram shows the parts of the nervous system involved in a reflex arc. Which letter identifies a synapse? section of the spinal cord A B D C

Answer

D

Question 191 mark

Question

A person looks at a distant object in a dark area. The person then moves to a bright area and looks at a near object. Which statement describes some of the changes that take place in the person’s eyes? A The circular muscles of the iris contract, the pupil constricts, the ciliary muscles relax and the lens gets thicker. B The radial muscles of the iris relax, the circular muscles of the iris contract, the pupil constricts and the lens gets thinner. C The radial muscles of the iris relax, the pupil constricts, the ciliary muscles contract and the lens gets thicker. D The radial muscles of the iris relax, the pupil dilates, the ciliary muscles relax and the lens gets thicker.

Answer

C

Question 201 mark

Question

Which effect does adrenaline have on blood glucose concentration and pulse rate? blood glucose pulse rate concentration A decreases decreases B decreases increases C increases decreases D increases increases

Answer

D

Question 211 mark

Question

The diagram shows an experiment using two wheat shoot tips, X and Y. after two days in even light shoot tip removed X Y X Y Which statement is supported by the evidence provided by this experiment? A Auxin moves through the plant by osmosis. B Auxin is made in the shoot tip. C Auxin is unequally distributed in response to light. D Auxin inhibits cell elongation.

Answer

B

Question 221 mark

Question

Which action would help to limit the development of antibiotic resistance in bacteria? A Use antibiotics frequently to prevent infection by antibiotic-resistant bacteria. B Use antibiotics only to treat bacterial infections. C Use antibiotics to treat all types of infections. D Use antibiotics to treat only viral infections.

Answer

B

Question 231 mark

Question

What is an example of asexual reproduction? A a single bacterium dividing to produce two genetically identical bacteria B a mammal giving birth to four offspring C a female bird laying six eggs which will hatch into the same species D a tomato plant producing fruits which contain many seeds

Answer

A

Question 241 mark

Question

The diagram shows parts of two different plants, 1 and 2, of the same species. The transfer of pollen between the flowers of these two plants is shown by the arrows labelled P and Q. P Q 1 2 Which arrows show cross-pollination, and which transfer of pollen would produce the most variation in the offspring? transfer of pollen that produces the cross-pollination most variation in the offspring A P only P B P only Q C P and Q P D P and Q Q

Answer

A

Question 251 mark

Question

Which substance is a hormone that is involved in the development and regulation of male secondary sexual characteristics? A insulin B glucagon C lactase D testosterone

Answer

D

Question 261 mark

Question

Which statement describes the net direction of movement of a substance across the placenta? A Carbon dioxide moves from the mother’s blood to the fetus’s blood. B Glucose moves from the fetus’s blood to the mother’s blood. C Glycogen moves from the mother’s blood to the fetus’s blood. D Urea moves from the fetus’s blood to the mother’s blood.

Answer

D

Question 271 mark

Question

The diagram shows the human female reproductive system. Which label identifies the uterus? B A C D

Answer

C

Question 281 mark

Question

Which methods can transmit HIV? 1 hugging a person infected with HIV 2 sharing a needle with a person infected with HIV 3 using a plate that a person infected with HIV has used A 1, 2 and 3 B 1 only C 2 and 3 only D 2 only

Answer

D

Question 291 mark

Question

Which chromosomes can be found in a single sperm? A X and X B X and Y C X or X D X or Y

Answer

D

Question 301 mark

Question

Why are lymphocytes the only cells that produce antibody proteins? A Lymphocytes express all the genes in the nucleus. B Lymphocytes have twice as many genes as other cells. C Other cells do not have the genes for antibodies. D The genes for antibodies are only expressed in lymphocytes.

Answer

D

Question 311 mark

Question

During protein synthesis, what is the function of the ribosome? A It assembles amino acids in a chain. B It carries a copy of a gene to the cytoplasm. C It contains the code for the synthesis of a protein. D It determines the order of bases in the protein.

Answer

A

Question 321 mark

Question

The photograph shows a speckled chicken. Speckled chickens have white feathers and black feathers. When a chicken with only white feathers and a chicken with only black feathers are crossed, all of the offspring are speckled. What would be the expected phenotypic ratio if a speckled chicken was crossed with a chicken with only white feathers? A all offspring have only white feathers B all offspring are speckled C 1 white feathers only : 1 speckled D 3 white feathers only : 1 speckled

Answer

C

Question 331 mark

Question

What are stem cells? A specialised cells that divide by meiosis to produce daughter cells B specialised cells that divide by mitosis to produce daughter cells C unspecialised cells that divide by meiosis to produce daughter cells D unspecialised cells that divide by mitosis to produce daughter cells

Answer

D

Question 341 mark

Question

What are features of hydrophytes which have leaves that float? A long root system B many stomata on upper surface of leaves C hairy leaves D small air spaces in the spongy mesophyll

Answer

B

Question 351 mark

Question

Which unit could be used for the measurements needed to construct a pyramid of energy? A kJ per g per m2 B kJ per kg per year C kJ per m2 per year D kJ per kg

Answer

C

Question 361 mark

Question

Which process needs microorganisms to break down protein to produce ammonium ions? A decomposition B denitrification C nitrification D nitrogen fixation

Answer

A

Question 371 mark

Question

The graph shows part of a growth curve for a bacterial population. population size time What is not shown in the graph? A the death phase B the exponential phase C the lag phase D the stationary phase

Answer

A

Question 381 mark

Question

What is an advantage of large scale monocultures? A increased biodiversity B increased crop yield C increased susceptibility to disease D increased variation in the crop plant

Answer

B

Question 391 mark

Question

The graph shows the global emissions of carbon dioxide and methane from 1990 to 2015. 40 000 35 000 30 000 emissions 25 000 key / million 20 000 carbon dioxide tonnes 15 000 methane 10 000 5000 0 1990 1995 2000 2005 2010 2015 year A student makes four statements about carbon dioxide and methane. ● Carbon dioxide and methane were the only sources of greenhouse gases produced in 1990. ● Carbon dioxide emissions continue to rise to the present day. ● Carbon dioxide has a greater effect on climate change than methane. ● Methane emissions were lower than carbon dioxide emissions between 1990 and 2015. How many statements are supported by these data? A 1 B 2 C 3 D 4

Answer

A

Question 401 mark

Question

The diagram shows a bacterium. Which structure is cut to form sticky ends during genetic modification? A B D C

Answer

C

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0610/22 questions

Where can I find the 0610/22 October/November 2025 mark scheme?

On this page, free: the mark scheme for IGCSE Biology 0610/22, October/November 2025 (0610_w25_ms_22), and the question paper (0610_w25_qp_22), to read or download, with each question's marking points written out underneath.

How many marks is 0610/22 out of?

Biology 0610/22 for October/November 2025 is out of 40 marks, with 45 minutes to answer it.

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Yes. Upload your answers to 0610/22/O/N/25 as a PDF or photos, and CIE Buddy marks every question against this paper's official mark scheme, using Cambridge's marking rules. You get your score, each lost mark explained on your own script, and the topics to revise. It's a guide, not an official Cambridge grade.